Which route is listed for naloxone administration?

Which route is listed for naloxone administration?

• A. Intranasal
• B. Oral
• C. Subcutaneous
• D. Intramuscular Autoinjector

Answer: (A)

Naloxone is listed as an intranasal route because delivering it through the nasal mucosa provides rapid absorption without needles, making it quick and easy for bystanders or responders to administer and reverses opioid effects promptly. The oral route isn’t effective for an acute overdose since naloxone has poor oral bioavailability and acts too slowly. A subcutaneous route can work but is generally slower and less reliable in emergencies. An intramuscular autoinjector is another valid route, but it uses an injection rather than nasal spray, so it isn’t the intranasal option being identified here.

Naloxone is listed as an intranasal route because delivering it through the nasal mucosa provides rapid absorption without needles, making it quick and easy for bystanders or responders to administer and reverses opioid effects promptly. The oral route isn’t effective for an acute overdose since naloxone has poor oral bioavailability and acts too slowly. A subcutaneous route can work but is generally slower and less reliable in emergencies. An intramuscular autoinjector is another valid route, but it uses an injection rather than nasal spray, so it isn’t the intranasal option being identified here.